Barclaycard has come under fire over proposals to cut 285 back office and call centre staff and send the work they do abroad.
The bulk of the job losses with fall on the bank's site at Wavertree Technology Park in Liverpool, where 197 people will be axed. Northampton will lose 77 jobs to offshoring and eleven roles in Teeside will also be hit.
The latest cuts come just a week after the bank announced plans to slash 1000 branch-based financial planning advisors.
Labour union Unite has hit out at the latest job cut. Rob MacGregor, Unite national officer, says: "At this time of economic uncertainty why isn't this UK finance company doing all it can support its workforce in the UK, not telling them their work will now be done in India."
The bank says it has recently renewed its lease at Wavertree and is committed to the site. It says it will seek to redeploy staff affected by the offshoring decision at other locations where possible.